NAD+ Levels and Healthy Aging go Hand-in-Hand

Research published in Nature Aging “suggests that a clear association exists between NAD+ and health status in human aging.” NAD+ (nicotinamide adenine dinucleotide) is found in every cell in your body. It is essential to the chemistry that keeps you up and running.

Unfortunately, NAD+ levels decline universally as we age.

How can you increase your NAD+ levels? Basis is the evidence-based choice

We now have a way to safely and sustainably boost NAD+ levels. Developed by Dr. Leonard Guarente, a leader in the field of aging research, Basis was clinically proven to increase NAD+ levels by an average of 40% in a double-blind, randomized, placebo-controlled clinical trial published in the peer-reviewed journal Nature Partner Journals: Aging and Mechanisms of Disease.

Boosted NAD+ activates sirtuins, supports cellular energy and metabolism, targets cellular aging to promote a healthy cellular aging process, and helps maintain healthy DNA.

    Why is Basis unique among NAD+ supplements?

    Basis is clinically proven to safely and sustainably increase NAD+ by an average of 40% in humans. Elysium’s toxicology study also confirmed the superiority of the NR-E in Basis when compared to the published safety profiles of other NAD+ supplements, underscoring the company’s rigorous commitment to research and quality. 

    The synergistic combination of Elysium’s proprietary and high-purity nicotinamide riboside (NR-E) with potent antioxidant pterostilbene (PT) makes Basis extraordinarily effective. Basis is also third-party tested by independent labs both during and after manufacture for purity and quality, and is independently verified as NSF Certified for Sport.

    Basis 101: The Science

    • What is NAD+ and Why Is it Important?

      NAD+ is essential to the creation of energy in the body and the regulation of pivotal cellular processes. Here’s why it’s so important, h...

    • What Is Nicotinamide Riboside?

      This form of Vitamin B could be the key to restoring NAD+ levels — here’s why.

    • What is Pterostilbene?

      A cousin to resveratrol but more potent—pterostilbene is found in certain berries and nuts and serves as a powerful antioxidant.

      Leonard Guarente, Ph.D.

      Elysium co-founder & chief scientist

      "Given the momentum in human studies targeting aging, we are optimistic that the course of human health could be fundamentally changed."

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      • Internationally Renowned Scientific Advisors

      • certified for sport+ 3rd-Party Testedfor Purity & Quality

      • Ongoing + Completed Human Clinical Trials

      • tier-1 research collaborations and partnerships

        Basis benefits

        Promote cellular energy and reduce general tiredness and fatigue.

        Fight aging at the cellular level and protect your DNA from stressors.

        Support collagen and ceramide synthesis for healthy skin.

        Support healthy muscle function.

        Frequently Asked Questions

        Why are sirtuins important for aging?

        Sirtuins are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. Homeostasis involves keeping the cell in balance. However, sirtuins can only function in the presence of NAD+, nicotinamide adenine dinucleotide, a coenzyme found in all living cells.

        Collapsible rowWhat is Nicotinamide Adenine Dinucleotide (NAD+) and why is it important?

        NAD+, or nicotinamide adenine dinucleotide, is a critical coenzyme found in every cell in your body, and it’s involved in hundreds of metabolic processes — but NAD+ levels decline with age. NAD+ has two general sets of reactions in the human body: Helping turn nutrients into cellular energy as a key player in metabolism and working as a helper molecule for proteins that regulate other cellular functions. These processes are incredibly important.

        What is Nicotinamide Riboside (NR) and why is it important?

        This form of Vitamin B could be the key to increasing NAD+ levels — here’s why. Nicotinamide riboside is often called NR for short, and it’s a precursor to NAD+, meaning it's the raw material from which your body makes NAD+ through a series of chemical transformations. Human clinical studies, including ours, have shown efficacy of NR supplements in increasing NAD+ levels.

        What is Pterostilbene and why is it important?

        Pterostilbene is a polyphenol, a type of molecule that occurs in plants, particularly small berries and nuts. Blueberries are a particularly rich source of pterostilbene; although it is found in grapes, pterostilbene (unlike its cousin resveratrol) doesn’t survive the wine-making process.

        What’s a polyphenol?

        “Phenol” refers to a certain chemical structure (in this case, a hydroxyl group linked to a benzene ring); “poly” just means the molecules have more than one of the structure. One of polyphenols’ main jobs is to help the plant fight off pathogens. When eaten by humans, polyphenols may serve as powerful antioxidants.

        Is there anything I should notice once I start taking Basis?

        Basis is designed to work beneath the surface, so its primary purpose is not to deliver surface-level results. Taking Basis is an investment in the long-term health of your cells, and you may not feel different despite the improvements happening inside your body. Everyone’s physiology is unique and results vary from person to person.

        What are the results of your clinical trial?

        Elysium conducted a first-in-humans study demonstrating clearly that Basis can increase and sustain cellular NAD+ levels. Participants in the trial experienced a 40% average increase in cellular NAD+ levels within a month, which was maintained for the duration of the trial. We also tested a variety of biological markers to add to the existing body of evidence confirming that the ingredients in Basis are safe.